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KMID : 1123920140280010022
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 1 p.22 ~ p.28
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Effects of Flos Sophorae Ethanol Extract on NF-kB Dependent MMP-9 Expression in Human Breast Cancer Cell
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Kim Jeong-Mi
Lee Young-Rae
Hwang Jin-Ki
Kim Mi-Seong
Kim Ha-Rim
Park Yeon-Ju
You Yong-Ouk
Kim Seong-Cheol
Ryu Do-Gon
Kwon Kang-Beom
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Abstract
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Flos Sophorae, the dried flower bud of Sophora japonica L, possesses anti-inflammatory properties, prevents and treats blood capillary and hypertension diseases and can also be used as a hemostat. However, the effect of Flos Sophorae on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in cancer cell invasion. In this study, we investigated the inhibitory effect of Flos Sophorae extract (FSE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in Michigan Cancer Foundation-7 (MCF-7) cells. FSE inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-κB). These results indicate that FSE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells. Thus, FSE may have therapeutic potential for controlling breast cancer invasiveness.
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KEYWORD
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MMP-9, NF-κB, Invasion, MCF-7 breast carcinoma cells
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